Hanging in the Balance: Fluid Homeostasis in Hibernation
Fundamental knowledge about how hibernation enables some species to survive over an entire winter without water has the immense potential to advance human medicine. This project will use the thirteen-lined ground squirrel as a model system to dissect and manipulate the neural circuits that regulate fluid balance across torpor and arousal states during hibernation.
Developing Therapeutic Protein Disaggregases for Neurodegenerative Disease
Hsp104 is a protein disaggregase that enables yeast to survive stress and maintain their fitness during replicative or chronological aging. Homologues of Hsp104 are missing from metazoa. We hope to rationally evolve Hsp104 in order to safely reverse deleterious protein aggregation so that we may combat age-associated neurodegeneration.
Neural Mechanisms Underlying Context-dependent Wind Guided Navigation in Drosophila
This project examines cognitive flexibility in spatial navigation in the fruit fly Drosophila and uses wind-guided navigation as a model. Flies change their walking direction relative to the wind based on whether or not there is an attractive odor, and we will investigate neural mechanisms underlying this flexible switching at the cellular and synaptic levels.
Discovering Mechanisms of Kabuki Syndrome Neurodevelopment Defects in Zebrafish and Human iPSC-Derived Brain Organoids
Children with Kabuki Syndrome (KS) have neurodevelopment defects that greatly impact the quality of life for KS children and their families. The cellular and molecular mechanisms by which KMT2D mutations cause these neurodevelopmental defects are unknown. We will use the experimental versatility and high-throughput capabilities of our KS zebrafish models and the translatability of KS patient iPSC-derived brain organoids to understand the novel roles of KMT2D during neurogenesis.
Acute Disruption of Disease Relevant Neuronal Protein
Human genetic studies have linked numerous neuronal proteins to neurodegenerative disease, but the functions of many of these proteins remain unclear thus hindering the development of effective therapies. In this project, I will apply our newly developed acute protein disruption technique along with advanced optical methods for monitoring neurotransmitter release, so that we may better understand the function of the Parkinson’s disease relevant protein α-synuclein.
WARREN ALPERT FOUNDATION:
Warren Alpert, (1920-2007), was a successful philanthropist and entrepreneur. He was the founder of Warren Equities, which Forbes Magazine listed as one of the top 500 privately owned companies. Mr. Alpert has been a generous philanthropist having established the Warren Alpert Foundation, a non profit organization which supports innovative individuals and organizations dedicated to understanding and curing disease through groundbreaking research, scholarship and service.
The focus of The Warren Alpert Foundation is to improve the health of the public through grants and programmatic activities progressing towards attaining or perfecting medical treatments or cures through basic research, translational and outcomes research as well as through health education.
BACKGROUND: The Warren Alpert Distinguished Scholars is a recently established program, now in its second year, that will support individual scientists of exceptional creativity who have an MD or PhD degree and who have completed a minimum of three years and not more than five years of a post-doctoral fellowship in the field of basic neurosciences at a medical school located in the United States.
These awards are given as transitional post-doctoral awards for recipients as they advance to become full time faculty members at the Assistant Professor level or higher. The medical school nominating each scholar will be awarded $200,000 annually for two years to cover their salary, lab costs, and related expenses. Up to fifteen percent of indirect costs is included in the $200,000. All applicants are required to provide 75% effort.
The dean of each U.S. located medical school is invited to nominate one candidate. Scholars will be chosen on the basis of the success in their prior post-doctoral work as well as in the importance and creativity of their continued work. The Foundation expects to make five awards in 2020.
The Foundation will select recipients for awards using an objective and nondiscriminatory selection process based upon criteria including a review of each applicant’s scholastic achievements, academic records, scientific proposal and submitted letters of recommendation.
APPLICATION PROCESS: Please download the below application and fill out according to the listed requirements. You must submit all requirements electronically to firstname.lastname@example.org no later than November 1, 2019.
NOTE: From time to time The Warren Alpert Foundation will elicit proposals in specific research and education areas.
Prospective applicants should submit a short 2 page letter of intent describing the program, its approximate budget, time line and its concordance with our mission statement.
Send letters of intent to:
The Warren Alpert Foundation
90 Elm Street – Suite 2
Providence, RI 02903
Letters of intent are reviewed quarterly prior to our quarterly meetings. (February, May, August & November)
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Photocopies of the three most recent 990PF's for The Warren Alpert Foundation are available upon request for a reasonable fee.
Send your requests via email to email@example.com and allow 30 days to process your request.